Regulation of lamin properties and functions: does phosphorylation do it all?

The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development. All essential lamin functions seem to depend o...

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Bibliographic Details
Published in:Open biology 2015-11, Vol.5 (11), p.150094
Main Authors: Machowska, Magdalena, Piekarowicz, Katarzyna, Rzepecki, Ryszard
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cdk1/pka/pkc
Chromatin Binding
Humans
Kinase Motif
Lamin Polymerization
Lamins - chemistry
Lamins - genetics
Lamins - metabolism
Molecular Sequence Data
Nuclear Envelope
Phosphorylation
Protein Processing, Post-Translational
Review
Signalling
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Summary:The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development. All essential lamin functions seem to depend on their capacity for assembly or disassembly after the receipt of specific signals, and after specific, selective and precisely regulated interactions through their various domains. Reversible phosphorylation of lamins is crucial for their functions, so it is important to understand how lamin polymerization and interactions are modulated, and which sequences may undergo such modifications. This review combines experimental data with results of our in silico analyses focused on lamin phosphorylation in model organisms to show the presence of evolutionarily conserved sequences and to indicate specific in vivo phosphorylations that affect particular functions.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.150094