The Stability and Screw Sense of the $\alpha$-Helix in Poly-$\beta$-Benzyl-L-Aspartate

A number of polymers and copolymers containing β-benzyl-L-aspartate has been prepared and their optical rotatory dispersion in a variety of solvents has been measured. The results of these measurements together with studies of infra-red spectra, X-ray diffraction patterns, deuteration rates and mole...

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Bibliographic Details
Published in:Proceedings of the Royal Society of London. Series A, Mathematical and physical sciences Mathematical and physical sciences, 1960-11, Vol.259 (1296), p.110-128
Main Authors: Bradbury, E. M., Downie, A. R., Elliott, A., Hanby, W. E.
Format: Article
Language:English
Subjects:
Atoms
Chemical composition
Chlorides
Copolymers
Molecular weight
Polymerization
Polymers
Solvents
Viscosity
Wavelengths
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Summary:A number of polymers and copolymers containing β-benzyl-L-aspartate has been prepared and their optical rotatory dispersion in a variety of solvents has been measured. The results of these measurements together with studies of infra-red spectra, X-ray diffraction patterns, deuteration rates and molecular models lead to the following conclusions. (i) The α-helical form of poly-β-benzyl-L-aspartate is considerably less stable relative to the solvated randomly coiled form than that of poly-γ-benzyl-L-glutamate. (ii) The left-handed α-helix of poly-β-benzyl-L-aspartate is more stable than the right-handed one. (iii) The difference in stability between the two senses of α-helix is much less in the case of poly-β-benzyl-L-aspartate than in that of poly-γ-benzyl-L-glutamate or poly-L-alanine.
ISSN:1364-5021
0080-4630
1471-2946
2053-9169
DOI:10.1098/rspa.1960.0214