The Effect of Hypoxanthine on the Growth of an Avian Tissue in vitro

The experiments described in this paper have shown that the purine base hypoxanthine, added in suitable concentration to a medium commonly used for tissue culture, is capable of markedly increasing both the rate and duration of the tissue growth. On the other hand, the related base adenine acts unfa...

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Bibliographic Details
Published in:Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1944-12, Vol.132 (868), p.253-257
Main Authors: Hopkins, Frederick Gowland, Simon-Reuss, Irmelin
Format: Article
Language:English
Subjects:
Body tissues
Chemical bases
Embryos
Hypoxia
Liquefaction
Mitosis
Mitotic index
Purines
Tissue culture techniques
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Summary:The experiments described in this paper have shown that the purine base hypoxanthine, added in suitable concentration to a medium commonly used for tissue culture, is capable of markedly increasing both the rate and duration of the tissue growth. On the other hand, the related base adenine acts unfavourably on the growth. The nature of the influence of the former base is perhaps not clear, but certain possibilities are discussed.
ISSN:0962-8452
0080-4649
2053-9193
1471-2954
2053-9193
DOI:10.1098/rspb.1944.0016