The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis

Despite advances in antimicrobials, vaccination and public health measures, infectious diseases remain a leading cause of morbidity and mortality worldwide. With the increase in antimicrobial resistance and the emergence of new pathogens, there remains a need for new and more accurate diagnostics, t...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2014-06, Vol.369 (1645), p.20130427
Main Authors: Blankley, Simon, Berry, Matthew Paul Reddoch, Graham, Christine M., Bloom, Chloe I., Lipman, Marc, O'Garra, Anne
Format: Article
Language:English
Subjects:
Biomarkers - blood
Communicable Diseases - diagnosis
Communicable Diseases - epidemiology
Communicable Diseases - microbiology
Drug Resistance, Microbial - genetics
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - physiology
Humans
Immune Response
Infection
Review
Systems Biology - methods
Transcriptome - genetics
Tuberculosis
Tuberculosis - genetics
Tuberculosis - microbiology
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Summary:Despite advances in antimicrobials, vaccination and public health measures, infectious diseases remain a leading cause of morbidity and mortality worldwide. With the increase in antimicrobial resistance and the emergence of new pathogens, there remains a need for new and more accurate diagnostics, the ability to monitor adequate treatment response as well as the ability to predict prognosis for an individual. Transcriptional approaches using blood signatures have enabled a better understanding of the host response to diseases, leading not only to new avenues of basic research, but also to the identification of potential biomarkers for use in diagnosis, prognosis and treatment monitoring.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.2013.0427