A highly adaptable catalyst/substrate system for the synthesis of substituted chromenesElectronic supplementary information (ESI) available: Full experimental procedures and spectra for new compounds. See DOI: 10.1039/c0cc01961e

The gold( i )-catalyzed endo -cyclization of o -(1-hydroxyallyl)phenols to form chromenes is reported. The title compounds are prepared in high yield from readily available substrates. The system tolerates both electron rich and deficient aryl rings and a high degree of substitution on the allyl moi...

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Bibliographic Details
Main Authors: Aponick, Aaron, Biannic, Berenger, Jong, Michael R
Format: Article
Language:English
Online Access:Get full text
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Summary:The gold( i )-catalyzed endo -cyclization of o -(1-hydroxyallyl)phenols to form chromenes is reported. The title compounds are prepared in high yield from readily available substrates. The system tolerates both electron rich and deficient aryl rings and a high degree of substitution on the allyl moiety. A dehydrative Au( i )-catalyzed endo -cyclization of o -(1-hydroxyallyl)phenols to form 2 H -chromenes in two steps from commercial materials.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc01961e