Asymmetric general base catalysis of the phospho-aldol reaction via dimeric aluminium hydroxidesElectronic supplementary information (ESI) available: Experimental details. CCDC reference numbers 749040 and 749041. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt00459f

Dimeric aluminium hydroxide complexes containing the ( R , R )- N , N ′-bis(2′-hydroxy-3′-organobenzyl)- trans -1,2-diaminocyclohexane ligand backbone effect catalysis of the phospho-aldol reaction under ambient, aerobic conditions at catalyst loadings of 0.5 mol% to afford enantioselectivities of c...

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Main Authors: Gledhill, Alexandra C, Cosgrove, Nichola E, Nixon, Tracy D, Kilner, Colin A, Fisher, Julie, Kee, Terence P
Format: Article
Language:English
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Summary:Dimeric aluminium hydroxide complexes containing the ( R , R )- N , N ′-bis(2′-hydroxy-3′-organobenzyl)- trans -1,2-diaminocyclohexane ligand backbone effect catalysis of the phospho-aldol reaction under ambient, aerobic conditions at catalyst loadings of 0.5 mol% to afford enantioselectivities of ca. 65%. Chiral dimeric aluminium hydroxide complexes effect aerobic, general base catalysis of the phospho-aldol reaction under ambient conditions at 0.5 mol% loadings to afford enantioselectivities of ca. 65%.
ISSN:1477-9226
1477-9234
DOI:10.1039/c0dt00459f