"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion siteElectronic supplementary information (ESI) available: Description of materials and methods, fluorescence microscopy images of cell morphology, quantitative analysis of cell morphology and SEM image of pre-mineralized scaffold. See DOI: 10.1039/c0nr00192a

• Main Authors: Xie, Jingwei, Li, Xiaoran, Lipner, Justin, Manning, Cionne N, Schwartz, Annie G, Thomopoulos, Stavros, Xia, Younan
• Format: Article
• Language: English
• ISSN: 2040-3364; 2040-3372
• DOI: 10.1039/c0nr00192a

We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions. We demonstrate the fabrication of "aligned-to-random" nanofiber scaffolds mimicking the structural organization of collagen fibers at the tendon-to-bone insertion site.