Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactorElectronic supplementary information (ESI) available: IR and NMR data. See DOI: 10.1039/c0ob00450b

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding b...

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Bibliographic Details
Main Authors: Malet-Sanz, Laia, Madrzak, Julia, Ley, Steven V, Baxendale, Ian R
Format: Article
Language:English
Online Access:Get full text
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Summary:A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method. First homogeneous and acid free method for the synthesis of sulfonyl chlorides from anilines, amenable to flow, safe and scalable.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00450b