Synthetic studies on the mycolactone coreElectronic supplementary information (ESI) available: Experimental details and copies of selected 1H-, 13C- and 2D NMR spectra have been provided. See DOI: 10.1039/c0ob00540a

Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the myc...

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Main Authors: Ko, Kwang-Seuk, Alexander, Matthew D, Fontaine, Shaun D, Biggs-Houck, James E, La Clair, James J, Burkart, Michael D
Format: Article
Language:English
Online Access:Get full text
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Summary:Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones. Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines RCM with a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00540a