The traceless Staudinger ligation for indirect 18F-radiolabellingThis publication is part of the web themed issue on fluorine chemistry.Electronic supplementary information (ESI) available: HPLC data of radiolabelling experiments. See DOI: 10.1039/c0ob00564a

The Staudinger ligation of phosphine-substituted thioesters with 18 F-fluoroethylazide has been successfully applied to access 18 F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated. The Staudinger ligation of pho...

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Main Authors: Carroll, Laurence, Boldon, Sophie, Bejot, Romain, Moore, Jane E, Declerck, Jérôme, Gouverneur, Véronique
Format: Article
Language:English
Online Access:Get full text
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Summary:The Staudinger ligation of phosphine-substituted thioesters with 18 F-fluoroethylazide has been successfully applied to access 18 F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated. The Staudinger ligation of phosphine-substituted thioesters with 18 F-fluoroethylazide has been successfully applied to access 18 F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00564a