A ternary supramolecular system containing a boronated DNA-metallointercalator, -cyclodextrin and the hexanucleotide d(GTCGAC)2Electronic supplementary information (ESI) available: synthesis and characterization of products, X-ray data for a (1S)-()-camphanate ester derivative of 1, table of selected chemical shift data of the free and bound hexanucleotide and S-1-CD2NO3, ROESY NMR spectra of S-1-CD2NO3, and details of the molecular modelling experiments. See DOI: 10.1039/c1cc15552k

• Main Authors: Ching, H. Y. Vincent, Buck, Damian P, Bhadbhade, Mohan, Collins, J. Grant, Rendina, Louis M
• Format: Article
• Language: English
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c1cc15552k

Solution NMR studies of the interaction between the hexanucleotide d(GTCGAC) 2 , -cyclodextrin and a boronated 2,2:6,2-terpyridineplatinum( ii ) complex containing 1,12-dicarba- closo -dodecaborane(12) (1,12- closo -carborane) reveal the formation of a remarkable ternary supramolecular system in which the terpyridine ligand is intercalated between the C 3 and G 4 bases, whilst the closo -carborane moiety is encapsulated by the cyclic sugar. A ternary supramolecular system consisting of a hexanucleotide, -cyclodextrin and a novel DNA metallointercalator containing a closo -carborane cage is reported.