In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytesDedicated to Daniel Dive on the occasion of his retirement.Electronic supplementary information (ESI) available: Description of experimental procedures, and experimental results of ICP-MS (Table S1) and elemental distribution (Fig. S1). See DOI: 10.1039/c1cc16211j

We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemica...

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Main Authors: Dubar, Faustine, Bohic, Sylvain, Slomianny, Christian, Morin, Jean-Charles, Thomas, Patrick, Kalamou, Hadidjatou, Gurardel, Yann, Cloetens, Peter, Khalife, Jamal, Biot, Christophe
Format: Article
Language:English
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Summary:We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical. We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16211j