Transfer hydrogenation with Hantzsch esters and related organic hydride donors

In recent years, Hantzsch esters and their related organic hydride donors have been widely utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions. Various compounds containing C&z.dbd;C, C&z.dbd;N and C&z.dbd;O unsaturated functionalities could be reduced...

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Bibliographic Details
Published in:Chemical Society reviews 2012-03, Vol.41 (6), p.2498-2518
Main Authors: Zheng, Chao, You, Shu-Li
Format: Article
Language:English
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Summary:In recent years, Hantzsch esters and their related organic hydride donors have been widely utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions. Various compounds containing C&z.dbd;C, C&z.dbd;N and C&z.dbd;O unsaturated functionalities could be reduced in the presence of organocatalysts or transition metal complexes, affording versatile chiral building blocks in high yields and excellent enantioselectivities under mild conditions. In this critical review , recent advances in this area are summarized and classified according to unsaturated functional groups being reduced and catalytic systems employed (91 references). This critical review summarizes recent development of catalytic asymmetric transfer hydrogenation (ATH) reaction mediated by Hantzsch esters and other related organic hydride donors.
ISSN:0306-0012
1460-4744
DOI:10.1039/c1cs15268h