Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: A perspective

This perspective discusses the uses of silver for both antimicrobial and anticancer applications. It focuses on the synthesis of silver N-heterocyclic carbene complexes (SCCs) and their in vitro efficacy against a broad spectrum of bacteria, as well as their antitumor properties. Finally, different...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2012-01, Vol.41 (2), p.327-336
Main Authors: Youngs, Wiley J, Knapp, Amanda R, Wagers, Patrick O, Tessier, Claire A
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Drug Carriers - chemistry
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - pharmacology
Humans
Methane - analogs & derivatives
Methane - chemistry
Methane - pharmacology
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Nanoparticles - chemistry
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Silver - chemistry
Silver - pharmacology
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Summary:This perspective discusses the uses of silver for both antimicrobial and anticancer applications. It focuses on the synthesis of silver N-heterocyclic carbene complexes (SCCs) and their in vitro efficacy against a broad spectrum of bacteria, as well as their antitumor properties. Finally, different polymeric nanoparticles are discussed as delivery vehicles for the encapsulation of SCCs and other therapeutic agents for use in vivo . This perspective discusses the uses of silver N-heterocyclic carbene complexes for both antimicrobial and anticancer applications with a focus on their encapsulation in polymeric nanoparticles.
ISSN:1477-9226
1477-9234
DOI:10.1039/c1dt11100k