Synthesis and properties of fluorescent dyes conjugated to hyperbranched polyglycerolsThis article is part of the themed issue Dendrimers II, guest-edited by Jean-Pierre Majoral.Electronic supplementary information (ESI) available. See DOI: 10.1039/c1nj20476a

Convergent syntheses of polyglycerol hyperbranched polymers containing fluorescent labels (fluorescein or perylene diimide (PDI)) at their core are presented. The hyperbranched polyglycerol (HPG) precursors were synthesized using a one step polymerization reaction wherein the initiator leaves a sing...

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Main Authors: Zill, Andrew T, Licha, Kai, Haag, Rainer, Zimmerman, Steven C
Format: Article
Language:English
Online Access:Get full text
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Summary:Convergent syntheses of polyglycerol hyperbranched polymers containing fluorescent labels (fluorescein or perylene diimide (PDI)) at their core are presented. The hyperbranched polyglycerol (HPG) precursors were synthesized using a one step polymerization reaction wherein the initiator leaves a single reactive group for dye functionalization. For further site isolation, allylated HPG was synthesized allowing cross-linking via ring closing metathesis and subsequent dihydroxylation to produce water-soluble, fluorescent nanoparticles. The dyes produced showed improvements in photostability, water solubility, or quantum yield, depending on both the dye used and cross-linking. These fluorescent nanoparticles outperformed similar dyes that incorporated linear polyethylene glycol (PEG) polymers. Hyperbranched polyglycerols solubilize perylenediimide (PDI) and improve its fluorescent properties.
ISSN:1144-0546
1369-9261
DOI:10.1039/c1nj20476a