Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activitiesElectronic supplementary information (ESI) available: 1H, 13C NMR spectra of all new compounds. See DOI: 10.1039/c1ob05144j

A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxida...

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Main Authors: Nam, Tae-gyu, Ku, Jin-Mo, Rector, Christopher L, Choi, Hoyoung, Porter, Ned A, Jeong, Byeong-Seon
Format: Article
Language:English
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Summary:A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants. A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05144j