Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorineElectronic supplementary information (ESI) available: Full experimental details. CCDC reference number 849762. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c1ob06380d

A short and efficient synthesis of an advanced intermediate ( 1 ) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy. A short and efficient synthesis of an advanced intermediate ( 1 ) in the Clive route to...

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Main Authors: Gignoux, Camille, Newton, Annabella F, Barthelme, Alexandre, Lewis, William, Alcaraz, Marie-Lyne, Stockman, Robert A
Format: Article
Language:English
Online Access:Get full text
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Summary:A short and efficient synthesis of an advanced intermediate ( 1 ) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy. A short and efficient synthesis of an advanced intermediate ( 1 ) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob06380d