Supramolecular hydrogels based on cyclodextrin-polymer polypseudorotaxanes: materials design and hydrogel properties

Supramolecular hydrogels formed by cyclodextrins (CDs) and polymers based on polypseudorotaxane formation have attracted great interest because of their potential applications as injectable hydrogel drug delivery systems due to their thixotropic nature and biocompatibility. Recent advancements in th...

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Bibliographic Details
Published in:Soft matter 2011-01, Vol.7 (24), p.1129-11297
Main Authors: Liu, Kerh Li, Zhang, Zhongxing, Li, Jun
Format: Article
Language:English
Subjects:
Biocompatibility
Cadmium
Cyclodextrins
Design engineering
Drug delivery systems
Hydrogels
Polymers
State of the art
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Summary:Supramolecular hydrogels formed by cyclodextrins (CDs) and polymers based on polypseudorotaxane formation have attracted great interest because of their potential applications as injectable hydrogel drug delivery systems due to their thixotropic nature and biocompatibility. Recent advancements in this area have led to improvements in the hydrogel rheological and drug delivery properties, marking a step forward towards practical applications. The development of novel CD-polypseudorotaxane hydrogels with new stimuli-responsive properties is another important progress in this area. These new developments are highlighted here from the perspective of materials design and hydrogel properties together with a state-of-the-art understanding on CD-polypseudorotaxane hydrogel formation. Due to their thixotropic property, supramolecular hydrogels derived from CD-polymer polypseudorotaxanes can be used as injectable hydrogels for controlled release applications. Recent advances brought about systems with improved rheological and controlled release behaviors as well as novel stimuli-responsive properties.
ISSN:1744-683X
1744-6848
DOI:10.1039/c1sm06340e