Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with CN chelate amido ligandsThis article is part of the ChemComm Chirality web themed issue.Electronic supplementary information (ESI) available: Experimental section and characterisation data for the products 2a2h. See DOI: 10.1039/c2cc30333g

The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution. DKR of racemic secon...

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Main Authors: Sato, Yasuhiro, Kayaki, Yoshihito, Ikariya, Takao
Format: Article
Language:English
Online Access:Get full text
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Summary:The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution. DKR of racemic secondary alcohols was achieved efficiently by the combined catalyst system of bifunctional amidoiridium complexes with CALB.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30333g