Time-gated luminescence microscopy with responsive nonmetal probes for mapping activity of protein kinases in living cellsElectronic supplementary information (ESI) available: Experimental details and further characterization. See DOI: 10.1039/c2cc33565d

A photoluminescence probe ARC-1185, possessing both high affinity towards basophilic protein kinases (PKs) and microsecond-scale luminescence lifetime when associated with a kinase, was used for the mapping of ARC-1185-PK complexes in living cells with time-gated luminescence microscopy. A photolumi...

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Main Authors: Vaasa, Angela, Ligi, Kadri, Mohandessi, Shabnam, Enkvist, Erki, Uri, Asko, Miller, Lawrence W
Format: Article
Language:English
Online Access:Get full text
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Summary:A photoluminescence probe ARC-1185, possessing both high affinity towards basophilic protein kinases (PKs) and microsecond-scale luminescence lifetime when associated with a kinase, was used for the mapping of ARC-1185-PK complexes in living cells with time-gated luminescence microscopy. A photoluminescence probe ARC-1185, possessing both high affinity towards basophilic protein kinases (PKs) and microsecond-scale luminescence lifetime when associated with a kinase, was used for the mapping of ARC-1185-PK complexes in living cells with time-gated luminescence microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33565d