AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interestElectronic supplementary information (ESI) available: Experimental procedures, spectral data for all new compounds, results of docking study. CCDC 859365. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2cc35757g

A conceptually new and straightforward introduction of sulfonyl groups at the C-7 position of an indole ring has been achieved via AlCl 3 mediated unexpected regioselective sulfonyl group migration for N -alkyl/aryl/heteroarylsulfonyl indoles affording potential inhibitors of Mycobacterium tuberculo...

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Main Authors: Prasad, Bagineni, Adepu, Raju, Sandra, Sandhya, Rambabu, D, Krishna, G. Rama, Reddy, C. Malla, Deora, Girdhar Singh, Misra, Parimal, Pal, Manojit
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Language:English
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Summary:A conceptually new and straightforward introduction of sulfonyl groups at the C-7 position of an indole ring has been achieved via AlCl 3 mediated unexpected regioselective sulfonyl group migration for N -alkyl/aryl/heteroarylsulfonyl indoles affording potential inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase. 7-Sulfonyl indoles are synthesized via a novel sulfonyl group migration strategy as potential inhibitors of chorismate mutase (CM).
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc35757g