Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine compositesElectronic supplementary information (ESI) available: Additional characterization data and experimental procedures. See DOI: 10.1039/c2cc36663k

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in...

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Main Authors: Leung, Ken Cham-Fai, Chak, Chun-Pong, Lee, Siu-Fung, Lai, Josie M. Y, Zhu, Xiao-Ming, Wang, Yi-Xiang J, Sham, Kathy W. Y, Cheng, Christopher H. K
Format: Article
Language:English
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Summary:Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration. Novel magnetic ternary nanocomposites are investigated for gene delivery and magnetic resonance imaging of gliobalstoma.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc36663k