[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-l-DOPAElectronic supplementary information (ESI) available. See DOI: 10.1039/c2cc38646a

The Ag-mediated electrophilic [ 18 F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [ 18 F]selectfluor bis(triflate) in acetone. The process gave 6-[ 18 F]fluoro- l -DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol −1 . The first...

Full description

Saved in:
Bibliographic Details
Main Authors: Stenhagen, Ida S. R, Kirjavainen, Anna K, Forsback, Sarita J, Jørgensen, Charlotte G, Robins, Edward G, Luthra, Sajinder K, Solin, Olof, Gouverneur, Véronique
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Ag-mediated electrophilic [ 18 F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [ 18 F]selectfluor bis(triflate) in acetone. The process gave 6-[ 18 F]fluoro- l -DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol −1 . The first example of Ag-mediated electrophilic [ 18 F]fluorination of an arylboronic acid is disclosed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc38646a