Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in waterElectronic supplementary information (ESI) available: Copies of 1H and 13C NMR spectra for target compounds. CCDC 894928 (3Ba). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2gc36301a

The report describes a gold( i ) complex and trifluoroacetic acid (TFA) cocatalyzed one-pot, Michael addition/intramolecular cyclization cascade reaction for the synthesis of unusual tetracyclic indoles containing a seven-membered ring in water with microwave irradiation (MW). This protocol presents...

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Main Authors: Xu, Shengtao, Zhou, Yu, Xu, Jinyi, Jiang, Hualiang, Liu, Hong
Format: Article
Language:English
Online Access:Get full text
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Summary:The report describes a gold( i ) complex and trifluoroacetic acid (TFA) cocatalyzed one-pot, Michael addition/intramolecular cyclization cascade reaction for the synthesis of unusual tetracyclic indoles containing a seven-membered ring in water with microwave irradiation (MW). This protocol presents an operationally simple, rapid and environmentally friendly strategy for preparing potential biologically interesting fused-indole molecular architectures from some simple starting materials. An environmentally friendly method was developed for the one-pot construction of tetracyclic indoles via a gold( i )-catalyzed cascade reaction in water.
ISSN:1463-9262
1463-9270
DOI:10.1039/c2gc36301a