Layer by layer assembly of heparin/layered double hydroxide completely renewable ultrathin films with enhanced strength and blood compatibilityElectronic supplementary information (ESI) available: more PUL results. See DOI: 10.1039/c2jm34728h

• Main Authors: Shu, Yingqi, Yin, Penggang, Liang, Benliang, Wang, Shasheng, Gao, Longcheng, Wang, Hao, Guo, Lin
• Format: Article
• Language: English
• ISSN: 0959-9428; 1364-5501
• DOI: 10.1039/c2jm34728h

Renewable nacre-like heparin (HEP)/layered double hydroxide (LDH) ultrathin films were first fabricated via a bottom-up layer by layer (LBL) deposition technique, which simultaneously showed largely enhanced mechanical properties and good blood compatibility. The results of UV-vis, FTIR, XRD and SEM analysis indicate that the HEP/LDH ultrathin films stacked densely together to form a well-defined brick-and-mortar structure. A strong electrostatic and hydrogen bond network at the organic-inorganic interface allowed the modulus of the film reach ca. 23 GPa, which was remarkably enhanced compared to previously reported polymer-LDH hybrid films. Due to the interlamellar heparin, the (HEP/LDH) n film may prove to be beneficial for new medical applications or as a replacement for conventional petroleum based plastics. Heparin(HEP)/layered double hydroxide (LDH) ultrathin films were fabricated via LBL deposition, which showed largely enhanced mechanical property ( E r 23 GPa) and good blood compatibility.