Chemical synthesis and biological study of 4β-carboxymethyl-epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortuneiElectronic supplementary information (ESI) available: Copies of NMR and IR spectra of compounds 12, 10, 13, 15a, 15b, 16 and 17 are provided as ESI. See DOI: 10.1039/c2md20082a

The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ. Compound 12 of Drynaria fortunei showed poten...

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Main Authors: Law, Man Chun, Wong, Ka Chun, Pang, Wai Yin, Wong, Man Sau, Chan, Tak Hang
Format: Article
Language:English
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Summary:The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ. Compound 12 of Drynaria fortunei showed potent proliferative activity on UMR-106 cells and selectively activate ERE-dependent gene transcription mediated by ERα.
ISSN:2040-2503
2040-2511
DOI:10.1039/c2md20082a