Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's diseaseElectronic supplementary information (ESI) available. See DOI: 10.1039/c2md20112g

The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2),...

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Main Authors: Im, Jungkyun, Kim, Sangjune, Jeong, Young-Hun, Kim, Wanil, Lee, Dohyun, Lee, Woo Sirl, Chang, Young-Tae, Kim, Kyong-Tai, Chung, Sung-Kee
Format: Article
Language:English
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Summary:The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum . A BBB-permeable derivative of trehalose was found to prevent the aggregation of polyQ in transfected cells and to significantly prolong lifespan and improve motor functions of the transgenic HD mouse model R6/2.
ISSN:2040-2503
2040-2511
DOI:10.1039/c2md20112g