Platinum(ii/iv) complexes containing ethylenediamine-N,N-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cellsElectronic supplementary information (ESI) available. CCDC 855121. For ESI and crystallographic data in CIF or other electronic format See DOI: 10.1039/c2mt20058a

• Main Authors: Kalu erovi, Goran N, Mijatovi, Sanja A, Zmejkovski, Bojana B, Bulatovi, Mirna Z, Gómez-Ruiz, Santiago, Moji, Marija K, Steinborn, Dirk, Miljkovi, Djordje M, Schmidt, Harry, Stoši -Gruji i, Stanislava D, Sabo, Tibor J, Maksimovi -Ivani, Danijela D
• Format: Article
• Language: English
• ISSN: 1756-5901; 1756-591X
• DOI: 10.1039/c2mt20058a

Several new R 2 eddp (R = i -Pr, i -Bu; eddp = ethylenediamine- N , N -di-3-propionate) esters and corresponding platinum( ii ) and platinum( iv ) complexes of the general formula [PtCl n (R 2 edda-type)] ( n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, 1 H and 13 C NMR) and elemental analysis. The crystal structure of platinum( iv ) complex [PtCl 4 {( c -Pe) 2 eddip}] ( 3a ) was resolved and is given herein. Ligand precursors, platinum( ii ), and platinum( iv ) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line. Several new R 2 eddp esters and corresponding platinum( ii ) and platinum( iv ) complexes of the general formula [PtCl n (R 2 edda-type)] ( n = 2, 4) were synthesized and characterized by spectroscopic methods and elemental analysis.