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Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetatesElectronic supplementary information (ESI) available: General experimental and characterization of all new compounds. See DOI: 10.1039/c2ob25962a
We report the palladium-catalyzed, pyrrolidine-mediated -benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed v...
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Main Authors: | , , |
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Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | We report the palladium-catalyzed, pyrrolidine-mediated -benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed
via
a Pd--benzyl complex generated from (coumarinyl)methyl acetates.
We report the palladium-catalyzed, pyrrolidine-mediated -benzylation of enamines which couples medicinally relevant coumarin moieties with aldehydes and ketones. |
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ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c2ob25962a |