Osmium(vi) nitrido complexes bearing azole heterocycles: a new class of antitumor agentsElectronic supplementary information (ESI) available: Detailed synthetic procedure and characterization of nitridoosmium complexes; instrumentation information; experimental procedures for X-ray crystallography, cellular uptake, cell viability assay, soft agar clonogenic assay, flow cytometric analysis, Western blot analysis, EdU incorporation, gamma H2AX staining, DNA migration assay. CCDC reference numbers

Eight new nitridoosmium( vi ) complexes with the general formula [Os VI (N)Cl 3 (Hazole) 2 ] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole...

Full description

Saved in:
Bibliographic Details
Main Authors: Ni, Wen-Xiu, Man, Wai-Lun, Yiu, Shek-Man, Ho, Man, Cheung, Myra Ting-Wai, Ko, Chi-Chiu, Che, Chi-Ming, Lam, Yun-Wah, Lau, Tai-Chu
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eight new nitridoosmium( vi ) complexes with the general formula [Os VI (N)Cl 3 (Hazole) 2 ] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives ( 1 , 2 , 3 and 4 ) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. A series of eight nitridoosmium( vi ) complexes bearing chloro and Hazole ligands has been prepared and characterized. The osmium( vi ) nitrido complexes 14 bearing pyrazole ligands show promising anti-cancer properties.
ISSN:2041-6520
2041-6539
DOI:10.1039/c2sc01031c