Tunable transmembrane chloride transport by bis-indolylureasElectronic supplementary information (ESI) available: Details of synthesis, stability constant determination, crystallography and supplementary membrane transport studies. Extended structureactivity relationship discussion, full computational details for molecular dynamics simulations and extended MD results discussion are also given. CCDC reference numbers 862708 and 862709. For ESI and crystallographic data in CIF or other electronic

• Main Authors: Haynes, Cally J. E, Moore, Stephen J, Hiscock, Jennifer R, Marques, Igor, Costa, Paulo J, Flix, Vtor, Gale, Philip A
• Format: Article
• Language: English
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c2sc20041d

A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayers. A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayers.