A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolinesElectronic supplementary information (ESI) available: Experimental details, characterization data, and NMR spectral charts. See DOI: 10.1039/c2sc20914d

An operationally simple, copper-catalyzed arylation of N -tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient te...

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Main Authors: Kieffer, Madeleine E, Chuang, Kangway V, Reisman, Sarah E
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Reisman, Sarah E
description An operationally simple, copper-catalyzed arylation of N -tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners. An operationally simple, copper-catalyzed arylation of N -tosyltryptamines to provide C3-aryl pyrroloindolines is reported.
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title A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolinesElectronic supplementary information (ESI) available: Experimental details, characterization data, and NMR spectral charts. See DOI: 10.1039/c2sc20914d
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