Functionalized liposome purification via Liposome Extruder Purification (LEP)Electronic supplementary information (ESI) available. See DOI: 10.1039/c3an00680h

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with...

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Bibliographic Details
Main Authors: Alves, Nathan J, Cusick, William, Stefanick, Jared F, Ashley, Jonathan D, Handlogten, Michael W, Bilgicer, Basar
Format: Article
Language:English
Online Access:Get full text
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Summary:Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step. Liposome Extruder Purification (LEP) rapidly purifies functionalized liposomes with >93% contaminant removal and >93% liposome recovery for diverse liposome formulations.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an00680h