One-pot total chemical synthesis of human α-synucleinElectronic supplementary information (ESI) available: Experimental section and supplementary figures. See DOI: 10.1039/c3cc45353g

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multipl...

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Bibliographic Details
Main Authors: Fauvet, Bruno, Butterfield, Sara M, Fuks, Jonas, Brik, Ashraf, Lashuel, Hilal A
Format: Article
Language:English
Online Access:Get full text
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Summary:Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein. We developed a three fragment, one-pot total chemical synthesis scheme of α-synuclein.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc45353g