On the antitumor properties of novel cyclometalated benzimidazole Ru(ii), Ir(iii) and Rh(iii) complexesElectronic supplementary information (ESI) available: Synthesis, characterization data and biological study details. CCDC 950001. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3cc46239k

Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also di...

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Main Authors: Yellol, Gorakh S, Donaire, Antonio, Yellol, Jyoti G, Vasylyeva, Vera, Janiak, Christoph, Ruiz, José
Format: Article
Language:English
Online Access:Get full text
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Summary:Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed. Organometallic complexes with smartly designed benzimidazole ligands exhibit promising anticancer activity towards a variety of cancer cell lines.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46239k