A tetrazine templated method for the synthesis of ternary conjugatesDedicated to Prof. Krishna N. Ganesh on his 60th birthday.Electronic supplementary information (ESI) available: General experimental procedures and spectral charts of all compounds. See DOI: 10.1039/c3cc46634e

Conjugation is an important reaction that enables coupling of molecules. Many protocols exist for the synthesis of binary conjugates from two different molecules or for the polyvalent display of a single molecule. There aren't many methods for the synthesis of ternary conjugates. However, metho...

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Main Authors: Venkateswara Rao, Boddu, Dhokale, Snehal, Rajamohanan, Pattuparambil R, Hotha, Srinivas
Format: Article
Language:English
Online Access:Get full text
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Summary:Conjugation is an important reaction that enables coupling of molecules. Many protocols exist for the synthesis of binary conjugates from two different molecules or for the polyvalent display of a single molecule. There aren't many methods for the synthesis of ternary conjugates. However, methods for ternary conjugation are important for understanding the interplay of interactions between three biomolecules (or any three molecules per se ). A strategy for ternary bioconjugation using inverse electron demand Diels-Alder reaction with tetrazine is studied. Ternary conjugation was demonstrated by the reaction of a model glyco-peptide binary conjugate with a fluorescent tagged olefin. Salient features of dichlorotetrazine are exploited for the synthesis of homodimeric, heterodimeric and ternary glycoconjugates.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46634e