A coumarin derivative as a fluorogenic glycoproteomic probe for biological imagingElectronic supplementary information (ESI) available: Materials, instrumentation, literature based chemical synthesis, and additional figures. See DOI: 10.1039/c3cc47323f

Fluorescence imaging in living cells is typically carried out using a functionalized fluorescent dye. But it often causes strong background noise under many conditions where washing is not applicable. Here, we report on a coumarin based fluorogenic probe, which can be used as a bioorthogonal-labelin...

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Main Authors: Rong, Lei, Liu, Li-Han, Chen, Si, Cheng, Han, Chen, Chang-Sheng, Li, Ze-Yong, Qin, Si-Yong, Zhang, Xian-Zheng
Format: Article
Language:English
Online Access:Get full text
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Summary:Fluorescence imaging in living cells is typically carried out using a functionalized fluorescent dye. But it often causes strong background noise under many conditions where washing is not applicable. Here, we report on a coumarin based fluorogenic probe, which can be used as a bioorthogonal-labeling tool for glycoproteins. The results indicated that the probe was able to image glycoproteins in living cells and it may also be suitable for intracellular imaging. We report on a coumarin based fluorogenic probe, which can be used as a bioorthogonal-labeling tool for glycoproteins. The results indicated that the probe was able to image glycoproteins in living cells and it may also be suitable for intracellular imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47323f