A novel 99mTc labelling strategy for the development of silica based particles for medical applicationsElectronic supplementary information (ESI) available. CCDC 968395. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3dt53019a

The reaction of high-valent fac -{ 99m TcO 3 } + complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future....

Full description

Saved in:
Bibliographic Details
Main Authors: Wuillemin, Michel A, Stuber, Wanda T, Fox, Thomas, Reber, Michael J, Brühwiler, Dominik, Alberto, Roger, Braband, Henrik
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reaction of high-valent fac -{ 99m TcO 3 } + complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates. The reaction of high-valent fac -{ 99m TcO 3 } + complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel stereoselective labelling procedure for silica based particles.
ISSN:1477-9226
1477-9234
DOI:10.1039/c3dt53019a