Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbesElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00204g

Several amphiphilic, chalcogen-based redox modulators have been synthesized which exhibit a widespread, yet in some instances also selective, biological activity which is most likely based on their ability to modulate the intracellular redox balance and to interact with cellular membranes and specif...

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Main Authors: Du, Peng, Viswanathan, Uma M, Khairan, Khairan, Buric, Tomislav, Saidu, Nathaniel E. B, Xu, Zhanjie, Hanf, Benjamin, Bazukyan, Inga, Trchounian, Armen, Hannemann, Frank, Bernhardt, Ingolf, Burkholz, Torsten, Diesel, Britta, Kiemer, Alexandra K, Schäfer, Karl-Herbert, Montenarh, Mathias, Kirsch, Gilbert, Jacob, Claus
Format: Article
Language:English
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Summary:Several amphiphilic, chalcogen-based redox modulators have been synthesized which exhibit a widespread, yet in some instances also selective, biological activity which is most likely based on their ability to modulate the intracellular redox balance and to interact with cellular membranes and specific proteins. Amphiphilic chalcogen-based redox modulators show cytotoxicity against cancer cells over ARPE-19 cells and microorganisms.
ISSN:2040-2503
2040-2511
DOI:10.1039/c3md00204g