Sequential catalysis for stereoselective synthesis of complex polyketides

Covering: the literature up to 2012 This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophil...

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Bibliographic Details
Published in:Natural product reports 2014-01, Vol.31 (4), p.456-467
Main Authors: Herkommer, Daniel, Schmalzbauer, Björn, Menche, Dirk
Format: Article
Language:English
Subjects:
Biological Products - chemical synthesis
Biological Products - chemistry
Catalysis
Cyclization
Molecular Structure
Polyketides - chemical synthesis
Polyketides - chemistry
Stereoisomerism
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Summary:Covering: the literature up to 2012 This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophilic addition and a Tsuji-Trost reaction, an innovative sequence relying on an oxidative diyne cyclization and regioselective opening, as well as sequential cross coupling strategies. The design and scope of these methods are discussed and applications in complex target syntheses presented. This review presents selected recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides and their successful application in complex target synthesis.
ISSN:0265-0568
1460-4752
DOI:10.1039/c3np70093c