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A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cellsElectronic supplementary information (ESI) available: Experimental details, characterization data and selected copies of NMR spectra. See DOI: 10.1039/c3ob42267d
A general probe designed to induce a cascading sequence of reactions on a target protein was efficiently synthesized. The cascading reaction sequence involved (i) ligand-directed azaelectrocyclization with lysine and (ii) the autooxidation-induced release of a fluorescence quencher from the labeled...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | A general probe designed to induce a cascading sequence of reactions on a target protein was efficiently synthesized. The cascading reaction sequence involved (i) ligand-directed azaelectrocyclization with lysine and (ii) the autooxidation-induced release of a fluorescence quencher from the labeled protein. The probe was linked to a cyclic RGDyK peptide to enable the selective visualization of integrin α
V
β
3
on the surfaces of live cells.
A general probe designed to induce a cascading sequence of reactions on a target protein was efficiently synthesized. |
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ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c3ob42267d |