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A multicomponent approach to the synthesis of N-sulfonyl β2,3-amino estersElectronic supplementary information (ESI) available: Full experimental procedures, characterization data and copies of 1H, 13C and 19F NMR spectra. See DOI: 10.1039/c3ob42353k

The multicomponent synthesis of α,β-disubstituted N -sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an org...

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Bibliographic Details
Main Authors: Gall, Erwan Le, Sengmany, Stéphane, Samb, Issa, Benakrour, Sabrina, Colin, Christopher, Pignon, Antoine, Léonel, Eric
Format: Article
Language:English
Online Access:Get full text
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Summary:The multicomponent synthesis of α,β-disubstituted N -sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an organocobalt as the initiator of a Mannich-like process. The multicomponent synthesis of α,β-disubstituted N -sulfonyl β-amino esters is described.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob42353k