CuAAC "click" active-template synthesis of functionalised [2]rotaxanes using small exo-substituted macrocycles: how small is too small?Electronic supplementary information (ESI) available: The experimental procedures, 1H, 13C and DOSY NMR, HR-ESMS and crystallographic data. CCDC 997798-997802. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4cc03077j

Two "small" 22- and 24-membered exo -alcohol functionalised pyridyl macrocycles are exploited in the CuAAC active-template synthesis of [2]rotaxanes. The 24-membered macrocycle forms [2]rotaxanes in good yields while the smaller 22-membered macrocycle does not lead to interlocked products....

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Main Authors: Noor, Asif, Lo, Warrick K. C, Moratti, Stephen C, Crowley, James D
Format: Article
Language:English
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Summary:Two "small" 22- and 24-membered exo -alcohol functionalised pyridyl macrocycles are exploited in the CuAAC active-template synthesis of [2]rotaxanes. The 24-membered macrocycle forms [2]rotaxanes in good yields while the smaller 22-membered macrocycle does not lead to interlocked products. A small readily synthesised 24-membered exo -alcohol functionalised pyridyl macrocycle can be exploited in the CuAAC active-template synthesis of functionalised [2]rotaxanes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03077j