Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF3 in aqueous mediaElectronic supplementary information (ESI) available: Full details of synthetic, mechanistic (PDF), and crystallographic (CIF) studies. CCDC 993889-993892. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4cc04930f

A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF 3 (from fluoroform) in aqueous media . The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyf...

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Main Authors: Lishchynskyi, Anton, Berthon, Guillaume, Grushin, Vladimir V
Format: Article
Language:English
Online Access:Get full text
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Summary:A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF 3 (from fluoroform) in aqueous media . The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules. A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF 3 (from fluoroform) in aqueous media . The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc04930f