An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc05983b

The upconversion nanoparticle (UCNP)-loaded polypeptide composite nanoparticles that present fast NIR-sensitivity and tunable sugar-targeting properties are fabricated, opening a new avenue for on-demand and targeted cancer therapy. The half maximal inhibitory concentration (IC 50 ) of the nanoparti...

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Main Authors: Liu, Gang, Zhou, Linzhu, Su, Yue, Dong, Chang-Ming
Format: Article
Language:English
Online Access:Get full text
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Summary:The upconversion nanoparticle (UCNP)-loaded polypeptide composite nanoparticles that present fast NIR-sensitivity and tunable sugar-targeting properties are fabricated, opening a new avenue for on-demand and targeted cancer therapy. The half maximal inhibitory concentration (IC 50 ) of the nanoparticles dropped 4.7-fold or 3.1-fold compared to non-targeted or non-irradiated counterparts. The UCNP-loaded polypeptide composite nanoparticles that present fast NIR-sensitivity and tunable sugar-targeting properties are fabricated, opening a new avenue for on-demand and targeted cancer therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05983b