A phenacrylate scaffold for tunable thiol activation and releaseElectronic supplementary information (ESI) available: Compound characterization data, assay protocols and spectra. See DOI: 10.1039/c4cc07343f

A thiol-selective 2-methyl-3-phenacrylate scaffold with spatiotemporal control over delivery of a cargo is reported. The half-lives of decomposition could be tuned from 30 min to 1 day and the scaffold's utility in thiol-inducible fluorophore release in cell-free as well as within cells is demo...

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Main Authors: Sankar, Rathinam K, Kumbhare, Rohan S, Dharmaraja, Allimuthu T, Chakrapani, Harinath
Format: Article
Language:English
Online Access:Get full text
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Summary:A thiol-selective 2-methyl-3-phenacrylate scaffold with spatiotemporal control over delivery of a cargo is reported. The half-lives of decomposition could be tuned from 30 min to 1 day and the scaffold's utility in thiol-inducible fluorophore release in cell-free as well as within cells is demonstrated. A scaffold for biological thiol mediated tunable activation and release of a cargo is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07343f