Signal enhancement of electrochemical biosensors via direct electrochemical oxidation of silver nanoparticle labels coated with zwitterionic polymersElectronic supplementary information (ESI) available: Experimental details for the synthesis, biofunctionalization and characterization of zwitterionic polymers and hybrid nanoparticles. Biosensor elaboration and voltammograms. See DOI: 10.1039/c4cc07474b

A new electrochemical label has been developed, which is made up of silver nanoparticles (AgNPs) coated with a mixture of zwitterionic and biotinylated zwitterionic polymers. These polymers improve colloidal stability in physiological medium and ensure biorecognition while direct electrochemical oxi...

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Bibliographic Details
Main Authors: Geagea, R, Aubert, P.-H, Banet, P, Sanson, N
Format: Article
Language:English
Online Access:Get full text
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Summary:A new electrochemical label has been developed, which is made up of silver nanoparticles (AgNPs) coated with a mixture of zwitterionic and biotinylated zwitterionic polymers. These polymers improve colloidal stability in physiological medium and ensure biorecognition while direct electrochemical oxidation of silver nanoparticles strongly enhances the detection signal. The resulting hybrid nanomaterials are used as labels in the electrochemical sensing of avidin using sandwich assays elaborated using the biotin-avidin biorecognition system. A new electrochemical label has been developed, which is made up of silver nanoparticles (AgNPs) coated with a mixture of zwitterionic and biotinylated zwitterionic polymers.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07474b