An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes: facile synthesis of chiral γ-lactols and trisubstituted γ-lactonesElectronic supplementary information (ESI) available. CCDC 926785-1035631. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4cc09686j

An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams. An org...

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Main Authors: Lin, Jun-Bing, Xu, Shi-Ming, Xie, Ji-Kang, Li, Hong-Yu, Xu, Peng-Fei
Format: Article
Language:English
Online Access:Get full text
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Summary:An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams. An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes has been developed, enabling highly enantioselective synthesis of γ-lactols, trisubstituted γ-lactones and γ-lactams.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc09686j