Nanoscale materials for hyperthermal theranostics

Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall...

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Bibliographic Details
Published in:Nanoscale 2015-04, Vol.7 (16), p.7115-7126
Main Authors: Smith, Bennett E, Roder, Paden B, Zhou, Xuezhe, Pauzauskie, Peter J
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
angiogenesis
Animals
Chemotherapy
Complement
Diagnostic Imaging
DNA-repair
Drug Carriers - chemistry
Drug delivery systems
Humans
Imaging
Magnetic resonance
Metal Nanoparticles - chemistry
nanoscale materials
NANOSCIENCE AND NANOTECHNOLOGY
Nanostructure
Nanostructures - chemistry
Nanotubes, Carbon - chemistry
Neoplasms - diagnosis
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
optical fluorescence
Patients
photoacoustic methods
Photochemotherapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
radioemission
Radiography
RADIOLOGY AND NUCLEAR MEDICINE
Reduction
Semiconductors
Theranostic Nanomedicine
therapeutic approach
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Summary:Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc .) that complement and extend the efficacy of traditional chemotherapy and surgery. This mini-review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods. Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake.
ISSN:2040-3364
2040-3372
2040-3372
DOI:10.1039/c4nr06164k