Lewis acid promoted dual bond formation: facile synthesis of dihydrocoumarins and spiro-tetracyclic dihydrocoumarinsElectronic supplementary information (ESI) available: 1H-NMR data of the known compounds and the copies of 1H and 13C-NMR spectra are provided. See DOI: 10.1039/c4ob00490f

Lewis acid (FeCl 3 ) mediated dual bond (C-C and C-O) formation for synthesis of 3,4-dihydrocoumarins is presented. This method has successfully delivered a number of dihydrocoumarins containing dense functionalities on the aromatic ring. Significantly, the present method enabled achieving dihydroco...

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Main Authors: Niharika, Pedireddi, Ramulu, Bokka Venkat, Satyanarayana, Gedu
Format: Article
Language:English
Online Access:Get full text
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Summary:Lewis acid (FeCl 3 ) mediated dual bond (C-C and C-O) formation for synthesis of 3,4-dihydrocoumarins is presented. This method has successfully delivered a number of dihydrocoumarins containing dense functionalities on the aromatic ring. Significantly, the present method enabled achieving dihydrocoumarins with tertiary as well as quaternary carbon atoms at the benzylic position. Gratifyingly, the novel spiro-tetracyclic lactones have also been dextrously prepared using this process. Lewis acid (FeCl 3 ) mediated dual bond (C-C and C-O) formation for synthesis of 3,4-dihydrocoumarins is presented.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00490f